준비중입니다.
 
 
 
2000 | 2001 | 2002
 
WHO Collaborating Centre Annual Report (2000)
 

1. Name of the centre

   
  WHO Collaborating Centre for Traditional Medicine
East-West Medical Research Institute, Kyung Hee University
   
2. Address
   
  #1 Hoeki-dong Dongdaemun-ku Seoul 130-702, Korea
Tel : 82-2-958-9080 (or 9081), Fax : 82-2-958-9083, E-mail : ewmri@khmc.or.kr
   
3. Head of the centre
   
  Professor Jin-Woo Kim, MD, PhD.
   
4. Terms of reference
   
 
(1) to cooperate with WHO in studying the best ways of harmonizing the existing dual medical system - Eastern and Western medicine - with a view to developing a workable unified medical care system;
(2) to carry out studies on the evaluation and standardization of acupuncture, moxibustion and herbal medicine in order to make easier their incorporation into the national medical care system;
(3) to provide training opportunities for foreign research scientists; and
(4) to promote the exchange of information on traditional medicine.
   
  Place and Date : Seoul, February 16, 2001
   
5. Work performed in relation to the terms of reference
   
  5.1. Research works performed in 2000
   
 
(1) Hyun-Taeg Shin, Seung-Uoo Shin, Jae-Chul Song, Seok-Hee Chung, Jong-Soo Lee, Sung-Soo Kim, Hyun-Dae Shin
Clinical Efficacy of Thermography in Lumbar Radiculopathy Journal of Oriental Rehabilitation Medicine 10(1):23-32, 2000
(2) Hyun-Taeg Shin, Seok-Hee Chung, Jong-Soo Lee, Sung-Soo Kim, Hyun-Dae Shin
A Study of the Clinical Application of Thermography in Musculoskeletal Disease
Dongguk J. of the Institute of Oriental Medicine 8(2):47-67, 2000
(3) Dong-Hyun Kim, Eun-Kyung Park, Eun-Ah Bae, Myung-Joo Han
Metabolism of Rhaponticin and Chrysophanol 8-ο-β-D-Glucopyranoside from the Rhizome of Rheum undulatum by Human Intestinal Bacteria and Their Anti-allergic Actions
Biol. Pharm. Bull. 23(7):830-833, 2000
(4) Dong-Hyun Kim, Mi-Jeong Song, Eun-Ah Bae, Myung-Joo Han
Inhibitory Effect of Herbal Medicines on Rotavirus Infectivity
Biol. Pharm. Bull. 23(3):356-358, 2000
(5) Sang-Bum Shim, Nam-Jae Kim, Dong-Hyun Kim
β-Glucuronidase Inhibitory Activity and Hepatoprotective Effect of 18β- Glycyrrhetinic Acid from the Rhizomes of Glycyrrhiza uralensis
Planta Medica 66:40-43, 2000
(6) Eun-Ah Bae, Sun-Young Park, Dong-Hyun Kim
Constitutive β-Glucosidases Hydrolyzing Ginsenosides Rb1 and Rb2 from Human Intestinal Bacteria
Biol. Pharm. Bull. 23(12):1481-1485, 2000
(7) Hyuck-Jai Choi, Nam-Jae Kim, Dong-Hyun Kim
Inhibitory Effects of Crude Drugs on α-Glucosidase
Archives of Pharmacal Research 23(2):261-266, 2000
(8) Sang-Bum Shim, Yo-Na Jo, Han-Suk Oh, Jae-Hwan Rew, Kyung-Tae Lee,
Nam-Jae Kim, Seong-Hoon Seo
Bioequivalence of Lanclic® Capsules to Prozac® Capsules (Fluoxetine 20mg)
J. of Korean Society of Health-System Pharmacists 17(1):167-172, 2000
(9) Nam-Jae Kim, Eun-Ah Jung, Hee-Jung Kim, Sang-Bum Shim, Jong-Woo Kim
Quality Evaluation of Various Dried Roots of Rehmannia glutinosa
Kor. J. Pharmacogn. 31(2):130-141, 2000
(10) Nam-Jae Kim, Eun-Ah Jung, Dong-Hyun Kim, Sang-In Lee
Studies on the Development of Antihyperlipidemic Drugs from Oriental Herbal Medicines(Ⅱ) - Antihyperlipidemic Effects of Oriental Herbal Medicines -
Kor. J. Pharmacogn. 31(2):190-195, 2000
(11) Hyuck-Jai Choi, Nam-Jae Kim, Dong-Hyun Kim
Inhibitory Effect of GE974 isolated from Gyrophora esculenta on α-Glucosidase
Kor. J. Pharmacogn. 31(2):196-202, 2000
(12) Hyuck-Jai Choi, Nam-Jae Kim, Dong-Hyun Kim
Hypoglycemic Effect of GE974 isolated from Gyrophora esculenta in Normal and Diabetic mice
Kor. J. Pharmacogn. 31(3):268-272, 2000
(13) Dong-Hyun Kim, Young-Kyung Rhee, Nam-Jae Kim, Jun-Bock Jang, Byung-Key Song
Studies on the Effects of Herbal medicines in the Pregnancy to the Fetus (Ⅲ) - Mutagenesis and chromosomal aberration of herbal medicines and their polyprescriptions -
J. Oriental Gynecology 13(2):1-8, 2000
(14) Dong-Hyun Kim, Young-Kyung Rhee, Nam-Jae Kim, Jun-Bock Jang,
Byung-Key Song
Studies on the Effects of Herbal medicines in the Pregnancy to the Fetus (Ⅲ) - Mutagenesis and chromosomal aberration of herbal medicines and their polyprescriptions -
J. Oriental Gynecology 13(2):1-8, 2000
(15) Tong-Hyun Nam, Young-Jae Park, Young-Bae Park
The Clinical Study of the Effect of Electrical Dermal Stimulation on Pulse Transit Time in Healthy Male
The J. of Korea Institute of Oriental Medical Diagnostics 4(2):85-89, 2000
(16) Ji-Hoon Kim, Byung-Il Min, D. Schmidt, Hye-Jung Lee, Dong-Suk Park
The difference between electroacupuncture only and electroacupuncture with manipulation on analgesia in rats
Neuroscience Letters 279:149-152, 2000
(17) Sung-Koo Lee, Myung-Hwan Kim, Hong-Ja Kim, Dong-Wan Seo, Sang-Soo Lee, Dong-Il Kim, Kyo-Sang Yoo, Yun-Ho Joo, Young-Il Min, Ji-Hoon Kim, Byung-Il Min
Effects of Electroacupuncture on Sphincter of Oddi Motility in Humans
The Korean J. of Gastrointestinal Motility 6(1):44-51, 2000
(18) Kyung-Tae Lee, Joo-Il Kim, Hee-Juhn Park, Ki-Oug Yoo, Yong-Nam Han,
Ken-ichi Miyamoto
Differentiation-Inducing Effect of Magnolialide, a 1β-Hydroxyeudesmanolide Isolated form Cichorium intybus, on Human Leukemia Cells
Biol. Pharm. Bull. 23(8):1005-1007, 2000
(19) Hee-Juhn Park, Sang-Hyuk Kwon, Ki-Oug Yoo, Il-Cheol Sohn,
Kyung-Tae Lee, Hyeong-Kyu Lee
Sesquiterpenes from the Leaves of Ligularia fischeri var. spiciformis
Planta Medica 66:783-784, 2000
(20) Kyung-Tae Lee, Il-Cheol Sohn, Hee-Juhn Park, Dong-Wook Kim,
Geun-Ok Jung, Kun-Young Park
Essential Moiety for Antimutagenic and Cytotoxic Activity of Hederagenin Monodesmosides and Bisdesmosides Isolated from the Stem Bark of Kalopanax pictus
Planta Medica 66:329-332, 2000
(21) Bruno Conti, Shuei Sugama, Yoon-Seong Kim, Cristina Tinti,
Ho-Cheol Kim, Harriet Baker, Bruce Volpe, Barbara Attardi, Tong Joh
Modulation of IL-18 Production in the Adrenal Cortex following Acute ACTH or Chronic Corticosterone Treatment
NeuroImmunoModulation 8:1-7, 2000
(22) Eun-Kyung Ryu, Seok-Hee Chung, Jong-Soo Lee, Sung-Soo Kim, Hyun-Dae Shin
Effects of Poria cocos Extract on the Changes of the Weight, Epididymal Fat Tissue, Serum and m-RNA in Visceral Fat of the Obese Rats induced by Fat Diet
Journal of Oriental Rehabilitation Medicine 10(2):81-98, 2000
(23) Sun-Hee Jeong, Jae-Dong Lee, Hyung-Kyun Koh, Byoung-Choul Ahn,
Do-Young Choi, Dong-Suk Park
A Study on the Effects of Bee Venom Aqua-Acupuncture on Pain related Neuronal activity in the Spinal Cord
The J. of Korea Acupuncture & Moxibustion Society 17(2):153-168, 2000
(24) Chan-Yol Park, Sang-Soo Nam, Chang-Hwan Kim, Jae-Dong Lee,
Sung-Keel Kang, Yun-Ho Lee, Byoung-Choul Ahn
Molecular Biological Study of Anti-cancer Effects of Bee Venom on Human Melanoma Cell
The J. of Korea Acupuncture & Moxibustion Society 17(2):169-186, 2000
(25) nsop Shim, J. I. Javaid, Sang-Eun Kim
Effect of Ginseng Total Saponin on Extracellular Dopamine Release Elicited by Local Infusion of Nicotine into the Striatum of Freely Moving Rats
Planta Medica 66:705-708, 2000
(26) Insop Shim, Je-Seong Won, Jin-Koo Lee, Dong-Keun Song,
Sang-Eun Kim, Sung-Oh Huh, Yung-Hi Kim, Hong-Won Suh
Modulatory effect of ginseng total saponin on dopamine release and tyrosine hydroxylase gene expression induced by nicotine in the rat
Journal of Ethnopharmacology 70:161-169, 2000
(27) Hye-Nam Kim, Hyung-Kyun Koh, Dong-Suk Park, Sung-Kil Kang,
Yong-Suk Kim, Yong-Tae Choi
Effect of the bee venom aqua-acupuncture on the neuronal activities of serotonergic system in brainstem
The J. of Korea Acupuncture & Moxibustion Society 17(2):119-138, 2000
(28) Jae-Soo Kim, Woo-Suk Choi, Yong-Suk Kim, Hyung-Kyun Koh,
Sung-Keel Kang, Chang-Hwan Kim
Clinical Study on Gadolinium-DPTA enhanced MRI of Bell's palsy
The J. of Korean Acupuncture & Moxibustion Society 17(3):87-98, 2000
(29) Tuk-Woo Lim, Jin-Woo Lee, Mu-Hyoung Lee
Effects of Licorice Extract on Proliferation and Melanization in Cultured Normal Human Melanocytes
The J. of Kyung Hee University Medical Center 16(2): 143-150, 2000
(30) Sang-Hyub Yoon, Jong-Soo Lee
Role of 17β-Estradiol on Brain Atrophy Following Cerebral Infarction
J. of Korean Oriental Medicine 21(4):3-9, 2000
(31) Ji-Hyeon Lee, Shin-Myoung Park, Jong-Hoon Yi, Young-Chul Kim,
Jang-Hoon Lee, Hong-Jung Woo
Research on the herb medicine assumed to suppress Hepatitis B virus
Journal of Oriental Medicine 5(1):91-95, 2000
   
The full context of No. 3, 4, 5, 6, 7, 16, 18, 19, 20, 21, 25, 26 and 31 were written in English.
   
  5.2. Publications in 2000
   
 
East-West Medical Research Institute Journal 1999 :
This book contains 26 articles which were researched and published in this institute. The journal is also attached.
   
  5.3. Newly acquired research equipments in 2000
   
 
(1) Gel document system
(2) Bench top centrifuge
(3) Refrigerated microcentrifuge
(4) Clean bench
(5) Deep freezer
(6) Microprocessor CO2 incubator
(7) Gradient PCR system
(8) Vaccum dryer
(9) Gel dry system
(10) Autoclave
   
  5.4. Education for WHO Visiting Fellow
   
  Three doctors from Myanmar visited our institute during September 6 to 8. The field for the visiting fellows was 'Research on the use of traditional and western medicines in the treatment of disease'. They were Dr. Myat Moe, Thaw Zin and May Aye Than.
   
  5.5. New Government Research Project
   
 

The Institute has got fund from the 'Korea Science And Engineering Foundation' in September 2000 as a new government research project, which is a 3-year program. The title of this project is 'Effects of acupuncture on alterations of immune responses evoked by hypothalamus lesions', and the content of this research plan is as follows;

A series of report demonstrated that the occurrence of the stress-associated diseases has consistently increased in recent decades. It also reported that the stress has a close relationship with the decrement of immune response to foreign antigens. There is no doubt that the neuronal system and the immune system do not exist separately, rather cooperate each other to sustain the homeostasis of human body. Recently several reports strongly suggested that the acupuncture therapy induces the analgesia through the neuronal pathway and it also modulates the immune responses.

The reduced immune responses by stress are believed to be as a result of cooperative interactions between the hypothalamus, pituitary grand and adrenal grand(H-P-A axis). Especially hypothalamus is the key element to connect the neuronal system with the immune system. In addition, it has been demonstrated that the selective destruction of the nucleus in the hypothalamus induces turbulence in immune and endocrine homeostasis. The acupuncture stimuli of natural killer cells(NK cell) and influence of the balance between CD4/CD8 T lymphocytes. However, there is neuro-immune system. Therefore, this study focus on the evaluating the acupuncture effects on the immune system the valuable information about the mechanisms of acupuncture therapy on the immune modulation.

This study will be performed as described previously. Briefly, the hypothalamic lesion will be made by the electric conduction with concentric bipolar electrode on the desired area in the Sprague-Dawley rats brain. After the surgery, the control analgesia effect by acupuncture will be tested by tail flick test and the cytokines(IL-1,IL_2,IL-6,TNF-α), ACTH and corticosterone will be determined by ELISA assay and radioimmuno assay. In order to evaluate the brain cytokines involved in acupuncture effect on the immune modulation, the level of messenger RNA of specific cytokine are determined by RT-PCR using the total RNA extracted from the hypothalamus. Based on the above experiments, specific ctyokine deficient knock out mouse will be utilized to confirm the previous results. Furthermore, the exact locations and relevant cytokines involved in acupuncture effects will be further accessed by blocking the expression of selective cytokines using microinjection of antisense oligonucleotide into the sub-area in the hypothalamus.

This study will not only support a valuable information to understand the mechanisms involved in acupuncture effect on the immune responses, but also provide the reasonable explanations to the patients about utilizing acupuncture therapy on the stress associated diseases.

   
  5.6. Vision 2000 Project, Kyung Hee University
   
  Principle investigator of the Vision 2000 Project is Professor Jin-Woo Kim, head of this institute. This project is composed of 2 teams; the 'Antiaging and Molecular Medicine Team' and the 'Pain and Neuroscience Team'. It was initiated in July 2000. The project was preceded by university task force team. The project was admitted and supported by university. The final goal of this project is make our university one of the top-3-private-universities in Korea. This project was carried out through cooperation between western medicine, oriental medicine and pharmacy. Each team receives research fund from university $240,000/year for 5 years.
   
  5.6.1. Antiaging and Molecular Medicine Team
   
  Title : Research and development of basic therapeutic modalities and new drugs in the third medicine
Primary Investigator : Sung-Woon Kim, MD. PhD,
Division of Endocrinology-Metabolism, Department of Internal Medicine,
Kyung Hee University School of Medicine.
   
  This team is composed of 5 groups : ① growth hormone(GH)-related working group, ② rheumatoid arthritis(RA) research group, ③ Alzheimer research group, ④ osteoporosis research group, ⑤ biofuctional analysis group. All groups were consisted with medical doctors, oriental medical doctors, research associates, and technicians.
   
  The characterization and projects of each group :
   
 

GH-related working group
To find out Antiaging effects of GH, Moxibustion and some herb drugs using molecular biology techniques.
- Moxibustion effects on anterior pituitary hormone secretion
- Moxibustion and GH can stimulation cytokines in splenocytes

RA research group
To figure out new treatment modalities of RA using GH, dendritic cell infusion into collagen-induced arthritis (CIA) animal model (DBA-1 mice) and acupuncture with placenta-extracted materials (Jahageo)
- Clinical study of drug containing acupuncture effect on RA patients.
- Preventive effects of dendritic cell infusion into RA patients.

Alzheimer research group
They used Alzheimer mice and detected drug effects of some oriental herb drugs, which were regarded as a behavioral modifier from ancient Korea.
- Herb drug effects on Alzheimer animal model.

Osteoporosis research group
Effective herb drugs were screening with animal models and assessed by a histomorphometric assay, then trying to find out new effective drugs to ameliorate osteoporosis.
- Specific herb drugs could accelerate bone fracture healing.
- Effective herb drug fraction can affect osteoblast function.

Biofunctional research group
This group was concerned about biofunctional stream of human body using sensitive electronic devices, named Cold-Warm detector (韓熱測定器) and applied oriental medical concept to biofunctional phenomena detected from special machines.
- Pulse rate was an early detector of hyper- and hypothyroidism patients.
   
  【 Antiaging and Molecular Medicine Team 】
   
 
   
  5.6.2. Pain and Neuroscience Team
   
 

Title : Studies of therapeutic modalities and new drugs on the east-west medicine
Primary Investigator : Sabina Lim, OMD. PhD.
Department of Meridian and Accupoint, College of Oriental Medicine, Kyung Hee University

This team is composed of 8 groups : ① rheumatoid arthritis(RA) with venom acupuncture research group, ② inflammation treatment salve research group, ③ poststroke central pain research group, ④ arthritis treatment research group, ⑤ pain treatment with acupuncture research group, ⑥ pain-controlling drug developing research group, ⑦ neuropathic pain model developing group, ⑧ drug for stoke treatment group. All groups were consisted with medical doctors, oriental medical doctors, research associates, and technicians too.

   
6. Research works to be planned in 2001
   
  6.1. Vision 2000 Project, Kyung Hee University
   
  The 2nd year of research on 'Research and development of basic therapeutic modalities and new drugs in the third medicine' and 'Studies of therapeutic modalities and new drugs on the east-west medicine' will be continued.
   
  6.2. Government Research Project
   
  The 2nd year of research on 'Effects of acupuncture on alterations of immune responses evoked by hypothalamus lesions' will be continued.
   
  6.3. International Conference
   
  We are planning to hold an international symposium in the year 2001. The outline of the symposium is as follows;

Title : The International Conference in commemoration of the 30th anniversary of the foundation of Kyung Hee University Medical Center and of the 20th anniversary of the International Day of Peace
Main Theme : The Cooperation of East-West Medicine in the 21st Century
Date : October 5 - October 6, 2001 (2 days)
Venue : General Lecture Building, Kyung Hee University
Speaker: 30 - 40 scholars (about 15 foreign speakers)
Budget : ₩300,000,000 (US$240,000)
Session : East-West Medicine, Medicine, Oriental Medicine, Dental Medicine,
Pharmacy, Nursing Science

   
  6.4. General Research Theme
   
 
(1)

Dong-Hyun Kim
 

Metabolism of natural products by human intestinal bacteria and their relation to biological activities

(2) Nam-Jae Kim
  Studies on the standardization of herbal medicines
  Studies on the efficacy of combined preparation of crude drug
  Studies on the crude drug processing
(3) Young-Bae Park
  The effect of the electrical acupuncture stimulation on pulse rate variability
(4) Kyung-Tae Lee
  Studies on the mechanism of sesquiterpene compounds-induced apoptosis and differentiation in human leukemia cells
  Evaluation of in vivo anti-tumor activities of sesquiterpene compounds
(5) Byung-Il Min
  Cloning of genes responsible for distinguishing between responder and non-responder to the acupuncture mediated analgesic effects
  Effect of electroacupuncture on the mechanical allodynia in rat model of neuropathic pain
  The expression pattern of CCK-A, CCK-B, receptors in rat hypothalamus comparing responder with non-responder to the electroacupuncture mediated analgesic effect
(6) Doo-Ik Lee
  Studies on therapeutic modalities of central post-stroke pain syndrome in the East-West Medicine
  Studies of pain therapeutic modalities on prognosis of stroke in the East-West Medicine
(7) Chang-Ju Kim
  Acupuncture increases cell proliferation in dentate gyrus after transient global ischemia in gerbils
  Screening of active substance from herbs for preventing ischemic neuronal damage
  Screening of active substance from herbs for pain control
(8) Jae-Dong Lee
  Clinical research of rheumatoid arthritis
  Clinical research of ankylosing spondylitis
(9) In-sop Shim
  Effect of acupuncture and herbal medicine on stress response
(10) Yong-Suk Kim
  Effect of electroacupuncture on NADPH-diaphorase and NPY in cerebral cortex of SHR
  Development of herbal medicine and acupuncture for diabetic therapy using experimental diabetic models
(11) Dong-Suk Park
  Effects of Acupuncture on Rheumatoid Arthritis by use of CIA (collagen induced arthritis) model
(12) Sang-Hyub Yoon
  Effect of ovary deprivation on increasement of serum 17β-Estradiol concentration of Dangkijakyaksan in cerebral infarcted female rats
(13) Young-Chul Kim
  Research of herb medicine on viral hepatitis : Effects of herb formula on improving liver function, protecting hepatocytes from destruction and on HBeAg seroconversion, etc.
  Research on the effects of herb medicine on alcohol induced liver injury
7. Evaluation
   
  A government research project funded by the 'Korea Science And Engineering Foundation' was initiated in September 2000. Further research projects are planned for 2001. In the year 2000, our institute has strengthened its research capabilities with the positive financial support of Kyung Hee University. We will continue our efforts on 'Vision 2000 Project, Kyung Hee University'. The International Conference will be held in October 2001. We hope that it will be a good opportunity to modernize traditional medicine, and to increase the cooperation between western and oriental medicine.
   
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